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The principal cytochrome P450 isoenzyme included appears to be CYP2E1, with CYP1A2 and CYP3A4 as additional pathways. Close to 85% of an oral dose appears from the urine inside 24 hours of administration, most as being the glucuronide conjugate, with small quantities of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity details.An op